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Gout occurs when too much uric acid builds up in the blood Sven Andrighetto Youth Jersey , a condition known as hyperuricemia. Excess uric acid can form needle-like crystals that collect in the joints, most commonly the big toe. Experts recognize that a goal in the treatment of gout is the reduction and maintenance of serum uric acid levels of less than 6.0 mgdL. Daily treatment with ULORIC may help reduce and maintain uric acid levels by blocking the enzyme that produces it, xanthine oxidase.


Uloric was studied and evaluated in multiple clinical trials involving more than 4,000 subjects, in some for up to five years. The largest Tyson Barrie Youth Jersey , pivotal, phase 3 clinical trial, CONFIRMS, demonstrated that ULORIC 80 mg was superior to ULORIC 40 mg and allopurinol 300200 mg (67 percent, 45 percent and 42 percent Semyon Varlamov Youth Jersey , respectively) at achieving serum uric acid levels of less than 6.0 mgdL at the final visit.


Uloric has an established safety profile with no dose adjustments in patients with mild-to-moderate renal impairment, a condition often associated with patients who have hyperuricemia and gout.


Uloric is a xanthine oxidase inhibitor indicated for the chronic management of hyperuricemia in patients with gout. ULORIC is not recommended for the treatment of asymptomatic hyperuricemia.


Uloric is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline. An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including ULORIC. If a gout flare occurs during treatment Patrick Roy Youth Jersey , ULORIC need not be discontinued. Prophylactic therapy (i.e., non- steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months. A higher rate of cardiovascular thromboembolic events was observed in patients treated with ULORIC (0.74 per 100 patient-years) than allopurinol (0.60 per 100 patient-years) in clinical trials. A causal relationship with ULORIC has not been established. Monitor for signs and symptoms of myocardial infarction (MI) and stroke. Transaminase elevations have been observed in ULORIC-treated patients. No dose-effect relationship for these transaminase elevations was noted. Monitor liver function tests periodically. Adverse
reactions occurring in at least 1 percent of ULORIC-treated patients, and, at least 0.5 percent greater than placebo, are liver function abnormalities Mikko Rantanen Youth Jersey , nausea, arthralgia, and rash.


Visit for more information on Uloric


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